Yazar "Pekel, Hanife" için listeleme
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Design and synthesis of novel cylopentapyrazoles bearing 1,2,3-thiadiazole moiety as potent antifungal agents
Giray, Betül; Karadağ, Ayşe Esra; Şavluğ İpek, Özgecan; Pekel, Hanife; Güzel, Mustafa; Başpınar Küçük, Hatice (Elsevier, 2020)In drug-resistant phytopathogenic fungi, there has been extensive research on microbiological and antifungal drug development. In this study, a novel series of cylopentapyrazole bearing a 1,2,3-thiadiazole ring 2a-e were ... -
Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro
Ferreira, Juliana C.; Fadl, Samar; İlter, Metehan; Pekel, Hanife; Rezgui, Rachid; Şensoy, Özge; Rabeh, Wael M. (John Wiley and Sons Inc, 2021)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), one of the most challenging global pandemics of the modern era. Potential treatment strategies against ... -
Hiperinsülinemi etkisiyle posttranslasyonel modifikasyona uğrayan enzimlerin dinamiğinin incelenmesi ve inhibitör moleküllerin araştırılarak in vitro ortamda test edilmesi
Pekel, Hanife (İstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, 2022)Farnesiltransferaz (FTaz) enzimi C-terminalinde CaaX motifi taşıyan proteinlerin posttranslasyonel modifikasyonundan sorumludur. Hiperinsülinemi koşulunda FTaz'ın Ser60α ve Ser62α rezidüleri fosforilasyona uğrayarak enzimatik ... -
Inhibition of SARS-CoV-2 main protease: A repurposing study that targets the dimer interface of the protein
Pekel, Hanife; İlter, Metehan; Şensoy, Özge (Taylor and Francis Ltd., 2022)Coronavirus disease-2019 (COVID-19) was firstly reported in Wuhan, China, towards the end of 2019, and emerged as a pandemic. The spread and lethality rates of the COVID-19 have ignited studies that focus on the development ... -
Mechanistic insight into impact of phosphorylation on the enzymatic steps of farnesyltransferase
Pekel, Hanife; Güzel, Mustafa; Şensoy, Özge (Wiley, 2022)Farnesyltransferase (FTase) is a heterodimeric enzyme, which catalyzes covalent attachment of the farnesyl group to target proteins, thus coordinating their trafficking in the cell. FTase has been demonstrated to be highly ... -
Synthesis, structural investigations, DNA/BSA interactions, molecular docking studies, and anticancer activity of a new 1,4-disubstituted 1,2,3-triazole derivative
Göktürk, Tolga; Sakallı Çetin, Esin; Hökelek, Tuncer; Pekel, Hanife; Şensoy, Özge; Aksu, Ebru Nur; Güp, Ramazan (American Chemical Society, 2023)We report herein a new 1,2,3-triazole derivative, namely, 4-(( 1-( 3,4-dichlorophenyl)-1H-1,2,3- triazol- 4-yl)methoxy)-2-hydroxybenzaldehyde, which was synthesized by copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). ...